Download Airway Mucus: Basic Mechanisms and Clinical Perspectives by John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. PDF

By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)

Conceptually unsavoury, airway mucus is key to homeostasis within the breathing tract. by contrast, while irregular, mucus contributes considerably to the pathophysiology of a few critical bronchial illnesses, together with bronchial asthma, persistent bronchitis and cystic fibrosis. This quantity presents extensive ranging and in-depth insurance of the clinical and scientific features of airway mucus. It commences with introductory chapters which handle the biochemical and molecular organic foundation of airway mucus and maintains with accomplished insurance of a number of the physiological and rheological elements of breathing secretions. The scientific features of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory ailments of the airway. the amount concludes with a dialogue of the healing features of the subject, either by way of the potential methods to the therapy of mucus hypersecretion and the interplay of those medications with airway mucus. Written via major specialists within the box, each one contribution presents a entire assessment of its specific topic. Reflecting the newest advances during this very important sector of respiration examine, this quantity may be of significant curiosity to scientists and clinicians operating within the box of airway secretions and similar areas.

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Extra resources for Airway Mucus: Basic Mechanisms and Clinical Perspectives

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Biochem J 316: 967 -975. 48. Breg J, Van Halbeek H, Vliegenthart JFG, Klein A, Lamblin G, Roussel P (1988) Primary structure of neutral oligosaccharides derived from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis, determined by combination of 500-MHz IH-NMR spectroscopy and quantitative sugar analysis: Structure of 19 oligosaccharides having the G1cNAcfJ(1-3)GaINAc-ol core (type 3) or the G1cNAcfJ(1-3)[GlcNAcfJ(1-6)]GaINAc-ol core (type 4). Eur J Biochem 171: 643-654.

1. Thornton et aI. the former two amino acids are the sites of O-glycan attachment via the linkage sugar N-acetylgalactosamine. The cysteine residues appear to be confined to the "naked" domains, which are likely to be folded and stabilised by disulphide bonds. Electron microscopy of mucins before and after reduction [4, 5] together with a wealth of physical data [4-7] has led us to propose that intact mucins are polymers formed from disulphide bond-linked monomers (subunits) joined end to end in a linear array.

79. Vishwanath S, Ramphal R (1985) Tracheobronchial mucin receptor for Pseudomonas aeruginosa: Predominance of amino sugars in binding sites. Infect Immun 48: 331-335. 80. Coles SJ, Reid LM (1978) Glycoprotein secretion in vitro by human airway: Normal and chronic bronchitis. Exp Molec Pathol29: 326-341. 81. Phipps RJ, Williams IP, Richardson PS, Pell J, Pack RJ, Wright N (1982) Sympathomimetic drugs stimulate the output of secretory glycoproteins from human bronchi in vitro. Clin Sci 63: 23-28.

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