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By F. F. (Editor); Nord

Advances in Enzymology and comparable components of Molecular Biology is a seminal sequence within the box of biochemistry, providing researchers entry to authoritative reports of the newest discoveries in all parts of enzymology and molecular biology. those landmark volumes date again to 1941, offering an unequalled view of the old improvement of enzymology. The sequence bargains researchers the newest figuring out of enzymes, their mechanisms, reactions and evolution, roles in complicated organic procedure, and their software in either the laboratory and undefined. each one quantity within the sequence beneficial properties contributions by means of top pioneers and investigators within the box from world wide. All articles are rigorously edited to make sure thoroughness, caliber, and clarity.

With its wide selection of themes and lengthy ancient pedigree, Advances in Enzymology and similar parts of Molecular Biology can be utilized not just via scholars and researchers in molecular biology, biochemistry, and enzymology, but additionally via any scientist drawn to the invention of an enzyme, its houses, and its functions.

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These data suggest that the dimensions of acid DNase certainly are such as to permit the formation of an ensyme-substrate complex with native DNA (diameter 20 b) such as postulated by our model. Note Added in Proof. After this manuscript had been submitted for publication, an article by Prof. M. Laskowski on “DNases and their use in the studies of primary structure of nucleic acids” has appeared (12a). The reader is referred to it for an extensive survey of recent literature in the area of deoxyribonucleases.

Effect on Lipid Metabolism. C. Effect on Protein and RNA Synthesis. D. Effect on the Fine Structure of Nerve Cells. . . . . . . . . . V. Concluding Remarks. References .................................................... 51 52 54 56 57 60 62 63 66 67 71 73 73 1. Introduction Aside from the two classes of hormones and inducers, one finds frequent reference in the literature to substances of another type, often classified as growth factors. Their definition is usually operational, since they have the common property of stimulating the growth of a given tissue or cell type.

In the latter case it was checked that recovery of activity was higher than 90%. This indicates that the protein does not dissociate at high dilution. 75, reported by Kates and McAuslan (94) for both spleen and HeLa cell acid DNase; we have no explanation for this lower value. 2, as estimated by lone electrophoresis on cellulose acetate. TABLE VII Physical Properties of Hog Spleen Acid Deoxyribonuclewe (121) 8 2 ~(svedbergs) ,w Dz0,,, lo--' cma/seca 6, ml/gb Mol. 1%. Value calculated from amino acid composition.

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