Download 5-HT4 Receptors in the Brain and Periphery by Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.) PDF

By Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

This e-book offers a entire, updated evaluation of the distribution, pharmacology and body structure of valuable 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes express a special pharmacology, distribution and serve as, of which the 5-HT4 receptor has been the most intensively studied lately, either from a easy study perspective and as a goal for novel therapeutics.

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56. Matsuyama S, Sakiyama H, Nei K. Identification of putative 5-hydroxytryptamine4 (5-HT 4 ) receptors in guinea pig stomach: the effect of TKS159, a novel agonist, on gastric motility and acetylcholine release. J Pharmacal Exp Ther 1996; 276:989-995. 57· Eglen RM, Bonhaus DW, Johnson LG et al. Pharmacological characterization of two novel and potent 5- HT 4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br J Pharmacol1995; 115:1387-1392. 58. Buchheit KH, Gamse R, Giger R et al.

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J Pharmacol Meth 1980; 4:227-230. 17. Banner SE, Smith Ml, Sanger GJ. 5-HT receptors and 5-hydroxytryptophan-evoked defacation in mice. Br J Pharmacol1993; 110:135P. 18. Bingham S, King BF, Rushant B et al. Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function. J Pharm Pharmacol1995; 47:219-222. 19. Banner SE, Smith MI, Bywater D et al. 5-HT4 receptor antagonism by SB 204070 inhibits 5-hydroxytryptophan-evoked defaecation in mice. Br J Pharmacol1993; 110:17P.

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